Hosack maternal grandfather, Francis Arden, in New York City. His father, a native of Elgin, Scot- land, came to America as a British artillery of- ficer and fought at the capture of Louisbourg. David entered Columbia College in 1786, but took his degree in arts at the College of New Jersey (Princeton) in 1789. He began his medi- cal studies in New York under Nicholas Ro- mayne, Philip Wright Post, and Samuel Bard, continued them in Philadelphia under Benjamin Rush, and in 1791 began practice in Alexandria, Va., expecting that city to become the federal capital. The following year, having meanwhile married Catharine Warner of Princeton, who bore him one child, he left his wife and child with his parents and sailed, in August, for further study abroad. Visiting his father's relatives in Scotland, he met socially most of the notables of Edinburgh and studied medicine and botany in that city. In London, later, he added mineralogy to his studies, and during his sojourn there read before the Royal Society a paper on vision which was published in the Philosophical Transactions for 1794. In that year he returned to America, bringing with him a mineralogical collection which he gave in 1821 to the college at Prince- ton. During the voyage he won distinction which contributed to his later professional repu- tation, by his successful handling of an outbreak of typhus among the steerage passengers. In 1795 he became professor of botany at Co- lumbia College and two years later, of materia medica, holding both positions until 1811. The success attending his treatment of his patients in the yellow fever epidemic of 1797 gained him a partnership with his former preceptor, Samuel Bard [q.v.], to whose practice he succeeded. In 1804 he was attending surgeon at the Burr- Hamilton duel. He was one of the first phy- sicians in America to use the stethoscope, to ad- vocate vaccination, and to limit the use of the lancet, and was the first surgeon in America to ligate the femoral artery for aneurysm (1808). He taught materia medica in the newly chartered College of Physicians and Surgeons, 1807-08, and in 1811 resigned from Columbia to become professor of the theory and practice of physic in the new institution. He held annual lectureships in materia medica and obstetrics, and from 1822 to 1826 was vice-president, but in the last-named year withdrew, with four other members of the faculty, to found the short-lived Rutgers Medical College, of which he was president till 1830. In 1820 he was in great part responsible for the founding of Bellevue Hospital. With his pupil, later his partner, John W. Francis [g.z>.], Hosack established the American Hoshour Medical and Philosophical Register, published 1810-14* He wrote a number of professional pa- pers, some of them collected in Essays on Vari- ous Subjects of Medical Science (vols. I, II, 1824; vol. Ill, 1830), and published A System of Practical Nosology (1819). His Lectures on the Theory and Practice of Physic, delivered at the College of Physicians and Surgeons, was issued posthumously in 1838. He was also the author of A Tribute to the Memory of the Late Caspar Wistar, M.D. (1818), A Biographical Memoir of Hugh Williamson (1820), and a Memoir of DeWitt Clinton (1829), and was one of the edi- tors of William Smith's History of the Late Province of New York (2 vols., 1829-30), pub- lished by the New York Historical Society. Although, according to his pupil Francis, Ho- sack "was acknowledged ... to have been the most eloquent and impressive teacher of scien- tific medicine and clinical practice this country has produced" (Old New York, p. 84), he was as prominent in the social and cultural life of his city as in the professional field. At his summer home in Hyde Park he established the Elgin Bo- tanical Garden, which has since become famous. He was a founder of the New York Historical Society and its president, 1820-28, and was an incorporator, 1808, of the American Academy of Fine Arts. "His house was the resort of the learned and the enlightened," says Francis, add- ing that it was once observed that DeWitt Clin- ton, Bishop Hobart, and Dr. Hosack "were the tripod upon which our city stood." Hosack's first wife died only a few years after their mar- riage, and in 1797 he married Mary Eddy of Philadelphia, the adopted daughter of Caspar Wistar [#.z/.]. She was the mother of nine chil- dren, one of whom was Alexander Eddy Hosack [g.z/.]. After her death, Hosack married as his third wife Mrs. Magdalena Coster, a cousin of Philip Hone [q.v.~\9 in whose diary he figures frequently. He died suddenly of apoplexy in the midst of his manifold activities. [Sketch by A. E. Hosack, in S. D. Gross, Lives of Eminent Am. Physicians and Surgeons (1861) ; sketch by J. W. Francis, in S. W. Williams, Am. Medic. Biog. (1845), and in Hist. Mag. (N. Y.)> June 1860; J. W. Francis, Old New York (ed. of 1866); Autobiog. of Samuel D. Gross (1887), II, 8/ff.; The Diary of Philip Hone (2 vols., 1889), ed. by Bayard Tuckennan; sketch, with A. B. Durand's engraving of portrait by Sully, in James Herring and J. B. Longacre, The Nat. Portr. Gallery of Eminent Americans, vol. II (1835) ; Pop. Sci. Monthly, Oct. 1895; Evening Post (N. Y.), Dec. 23,24, 1835.] E.P. HOSHOUR, SAMUEL KLINEFELTER (Dec. 9, i8os-Nov. 29, 1883), clergyman, pi- oneer educator in eastern Indiana, was born in Heidelburg township, York County, Pa., his great-great-grandfather having immigrated to 240